Prof. Dr.-Ing. Karol Leslaw Grela

Profile

Academic positionFull Professor
Research fieldsOrganic Molecular Chemistry,Natural Product Chemistry,Pharmacy
Keywordsorganic chemistry, organometalic chemistry, synthesis, Olefin Metathesis, medicinal chemistry

Current contact address

CountryPoland
CityWarszawa
InstitutionPolish Academy of Sciences
InstituteInstitute of Organic Chemistry

Host during sponsorship

Prof. Dr. Alois FürstnerMax-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr
Start of initial sponsorship01/06/1999

Programme(s)

1998Humboldt Research Fellowship Programme

Publications (partial selection)

2008Gułajski, Ł.; Michrowska, A.; Narożnik, J.; Kaczmarska, Z.; Rupnicki, L.; Grela, K. 'A Highly Active Aqueous Olefin Metathesis Catalyst Bearing a Quaternary Ammonium Group'. In: ChemSusChem, 2008, 103-109
2008Kirschning, A.; Harmrolfs, K.; Mennecke, K.; Messinger, J.; Schön, U.; Grela, K.: 'Evaluation of Selected Homo- and Heterogeneous Ru-based Metathesis Catalysts in Cross-Metathesis of Allylated 15-Propenyl Estrone Leading to New 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors' . In: Tetrahedron Lett., 2008, 3019-3022
2008Kirschning, A.; Gułajski, Ł.; Mennecke, K.; Meyer, A.; Busch, T.; Grela, K. 'Highly active ammonium tagged olefin metathesis catalyst for simplified purification'. In: Synlett, 2008, 2692-2696
2008Michrowska, A.; Grela, K. 'In a Quest for the Ideal Olefin Metathesis Catalyst'. In: Pure Appl. Chem., 2008, 31-43
2008Bieniek, M.; Michrowska, A.; Usanov, D. L.; Grela, K. 'In an Attempt to Provide a User's Guide to the Galaxy of Benzylidene, Alkoxybenzylidene and Indenylidene Ruthenium Olefin Metathesis Catalysts' . In: Chem. Eur. J., 2008, 806-818
2008Szadkowska, A.; Grela, K. 'Initiation at snail's pace: design and applications of latent olefin metathesis catalysts featuring chelating alkylidene ligands'. In: Curr. Org. Chem. , 2008, 1631-1647
2008Barbasiewicz, M.; Szadkowska, A.; Makal, A.; Jarzembska, K.; Wozniak, K.; Grela, K. 'Is the Hoveyda -Grubbs Complex a Vinylogous Fischer-Type Carbene? Aromaticity-Controlled Activity of Ruthenium Metathesis Catalysts'. In: Chem. Eur. J. , 2008, 9330-9337
2008Sashuk, V.; Samojlowicz, C.; Szadkowska, A.; Grela, K. 'Olefin Cross-Metathesis with Vinyl Halides' . In: Chem. Commun., 2008, 2468-2470
2008Sledź, P.; Mauduit, M.; Grela, K. 'Olefin metathesis in ionic liquids' . In: Chem. Soc. Rev., 2008, 2433-2442
2008Gułajski, Ł.; Sledź, P.; Lupa, A.; Grela, K.; 'Olefin metathesis in water using acoustic emulsification'. In: Green Chem. , 2008, 279-282
2008Grela, K. 'The joy and challenge of small rings metathesis' . In: Angew. Chem. Int. Ed., 2008, 5504-5507
2007Czernuszewicz, R. S.; Mody, V.; Zareba, A. A.; Zaczek, M. B.; Galezowski, M.; Sashuk, V.; Grela, K.; Gryko, D. T. ' Solvent-Dependent Resonance Raman Spectra of High-Valent Oxomolybdenum(V) Tris[3,5-bis(trifluoromethyl)phenyl]corrolate' . In: Inorg. Chem., 2007, 5616-5624
2007Bieniek, M.; Michrowska, A.; Gułajski, Ł.; Grela, K. 'A Practical Larger Scale Preparation of Second Generation Hoveyda-type Catalysts'. In: Organometallics, 2007, 1096-1099
2007Gawin, R.; Makal, A.; Woźniak, K.; Mauduit, M.; Grela, K.: 'Dormant Ruthenium Catalyst Bearing Chelating Carboxylate Ligand: In Situ Activation and Application in Metathesis Reactions ' . In: Angew. Chem. Int. Ed., 2007, 7206-7209
2007Rix, D.; Caïjo, F.; Laurent, I.; Gulajski, L.; Grela, K.; Mauduit, M. 'Highly Recoverable Pyridinium-Tagged Hoveyda-Grubbs Pre-catalyst for Olefin Metathesis. Design of the Boomerang Ligand Toward the Optimal Compromise Between Activity and Reusability' . In: Chem. Commun., 2007, 3771-3773
2007Barbasiewicz, M.; Bieniek, M.; Michrowska, A.; Szadkowska, A.; Makal, A.; Woźniak, K.; Grela, K. 'Probing of the Ligand Anatomy: Effects of the Chelating Alkoxy Ligand Modifications on the Structure and Catalytic Activity of Ruthenium Carbene Complexes'. In: Adv. Synth. Catal., 2007, 193-203
2007Gstrein, X.; Burtscher, D.; Szadkowska, A.; Barbasiewicz, M.; Stelzer, F.; Grela, K.; Slugovc, C.: 'Ruthenium Quinoline and Quinoxaline Complexes: Thermally Triggered Initiators for ROMP' . In: J. Polym Sci. Part A: Polym. Chem., 2007, 3494-3500
2007Clavier, H.; Grela, K.; Kirschning, A.; Mauduit, M.; Nolan, S. P.: 'Sustainable Concepts in Olefin Metathesis' . In: Angew. Chem. Int. Ed., 2007, 6786-6801
2006Michrowska, A.; Gułajski, Ł.; Kaczmarska, Z.; Mennecke, K.; Kirschning, A.; Grela, K.; 'A green catalyst for green chemistry: Synthesis and application of an olefin metathesis catalyst bearing a quaternary ammonium group'. In: Green Chem., 2006, 685-688
2006Bieniek, M.; Bujok, R.; Cabaj, M.; Lugan, N.; Lavigne, G.; Arlt, D.; Grela, K.; 'Advanced fine tuning of Grubbs/Hoveyda olefin metathesis catalysts: a further step toward an optimum balance between antinomic properties' . In: J. Am. Chem. Soc., 2006, 13652-13653
2006Michrowska, A.; Mennecke, K.; Kunz, U.; Kirschning, A.; Grela, K.; 'A New Concept for the Non Covalent Binding of a Ruthenium-based Olefin Metathesis Catalyst to Polymeric Phases: Preparation of a Catalyst on Raschig Rings'. In: J. Am. Chem. Soc., 2006, 13261-13267
2006Michrowska, A.; Gułajski, Ł.; Grela, K. 'A Simple and Practical Phase-Separation Approach to the Recycling of a Homogeneous Metathesis Catalyst' . In: Chem. Commun., 2006, 841-843
2006Bieniek, M.; Kołoda, D.; Grela, K.: 'A highly selective synthesis of unsymmetrically substituted sulfones via cross-metathesis of divinyl sulfone' . In: Org. Lett., 2006, 5689-5692
2006Grela, K.; Michrowska, A.; Bieniek, M.; 'Catalysts for New Tasks: Preparation and Applications of Tunable Ruthenium Catalysts for Olefin Metathesis' . In: Chem. Rec., 2006, 144-156
2006Vinokurov, N.; Michrowska, A.; Szmigielska, A.; Drzazga, Z.; Wójciuk, G.; Demchuk, O. M.; Grela, K.; Pietrusiewicz, K. M.; Butenschön, H. 'Homo and Cross Olefin Metathesis Coupling of Vinylphosphane Oxides and Electron Poor Alkenes: Access to P-Stereogenic Dienophiles'. In: Adv. Synth. Catal., 2006, 931-938
2006Bieniek, M.; Bujok, R.; Stępowska, H.; Jacobi, A.; Hagenkötter, R.; Arlt, D.; Jarzembska, K.; Woźniak, K.; Grela, K.; 'New Air-Stable Ruthenium Olefin Metathesis Precatalysts Derived from Bisphenol S'. In: J. Organomet. Chem., 2006, 5289-5297
2006Gułajski, Ł.; Michrowska, A.; Bujok, R.; Grela, K. 'New Tunable Catalysts for Olefin Metathesis: Controlling the Initiation Through Electronic Factors' . In: J. Mol. Catal.A: Chem., 2006, 118-123
2006Rix, D.; Clavier, H.; Gulajski, L.; Grela, K.; Mauduit, M.; 'Pyridinium-tagged ruthenium complex as efficient catalyst for Ring Closing Metathesis' . In: J. Organomet. Chem., 2006, 5397-5405
2006Barbasiewicz, M.; Szadkowska, A.; Bujok, R.; Grela, K. 'Structure and Activity Peculiarities of Quinoline and Quinoxaline Ruthenium Complexes--Novel Metathesis Catalysts' . In: Organometallics, 2006, 3599-3604
2006Sashuk, V.; Grela, K. 'Synthetic and Mechanistic Studies on Enyne Metathesis: A Catalyst Influence'. In: J. Mol. Catal. A: Chem., 2006, 59-66
2006Michrowska, A.; Gułajski, Ł.; Grela, K.; '«Green» catalysts for green chemistry: new concepts in olefin metathesis catalysts separation and reuse' . In: Chem. Today, 2006, 19-22
2005Grela, K.; Mennecke, K.; Kunz, U.; Kirschning A. 'Immobilisation of the Grubbs III olefin metathesis catalyst with polyvinyl pyridine (PVP)' . In: Synlett, 2005, 2948-2952
2005Mikus, A.; Sashuk, V.; Kędziorek, M.; Samojłowicz, C.; Ostrowski, S.; Grela, K. 'Olefin and Enyne Cross-Metathesis---New Tool for Synthesis of Alkenyl-substituted Azulenes ' . In: Synlett, 2005, 1142-1146
2004Sashuk, V.; Ignatowska, J.; Grela, K. 'A Fine-Tuned Molybdenum Hexacarbonyl/Phenol Initiator for Alkyne Metathesis'. In: J. Org. Chem., 2004, 7748-7751
2004Michrowska, A.; Bujok, R.; Harutyunyan, S.; Sashuk, V.; Dolgonos, G.; Grela, K. 'Nitro-Substituted Hoveyda-Grubbs Ruthenium Carbenes: Enhancement of Catalysts Activity through Electronic Activation'. In: J. Am. Chem. Soc., 2004, 9318-9325
2004Bujok, R.; Bieniek, M.; Masnyk, M.; Michrowska, A.; Sarosiek, A.; Stępowska, H.; Arlt, D.; Grela, K.: 'Ortho- and Para-Substituted Hoveyda-Grubbs Carbenes. An Improved Synthesis of Highly Efficient Metathesis Initiators' . In: J. Org. Chem., 2004, 6894-6896
2004Michrowska, A.; Wawrzyniak, P.; Grela, K.: 'Synthesis of Macrocyclic Carbonates with Musk Odor by Ring-Closing Olefin Metathesis'. In: Eur. J. Org. Chem. , 2004, 2053-2056
2004Sashuk, V.; Koszarna, B.; Winiarek, P.; Gryko, D. T.; Grela, K.: 'The simple synthesis of stable A3- and trans-A2B-molybdenum(V) corrolates' . In: Inorg. Chem. Commun., 2004, 871-875
2003Karol Leslaw Grela, A. Michrowska, M. Bieniek, M. Kim, R. Klajn: Cross-metathesis reaction of vinyl sulfones and sulfoxides. In: Tetrahedron, 2003, 4525-4531
2003M. O. Demchuk, K. M. Pietrusiewicz, A. Michrowska, Karol Leslaw Grela: Synthesis of Substituted P-Stereogenic Vinylphosphine Oxides by Olefin Cross-Metathesis. In: Org. Lett., 2003, 3217-3220
2003Karol Leslaw Grela, M. Kim: good Bargain: An Inexpensive Air-Stable Ruthenium Matathesis Catalyst Derived from - Asarone. In: Eur. J. Org. Chem., 2003, 963-966
2002Karol Leslaw Grela, Syuzanna Harutyunyan, Anna Michrowska: A Highly Efficient Ruthenium Catalyst for Metathesis Reactions. In: Angew. Chem, 2002, 4210-4212
2002Karol Leslaw Grela, Mariusz Tryznowski, Michal Bieniek: A PS-DES immobilized ruthenium carbene: a robust and easily recyclable catalyst for olefin metathesis. In: Tetrahedron Letters, 2002, 9055-9059
2002Karol Leslaw Grela, J. Ignatowska: An Improved Catalyst for Ring Closing Alkyne Metathesis Based on Molybdenum Hexacarbonyl/2-Fluorophenol. In: Org. Lett., 2002, 3747-3749
2001Dr. Karol Leslaw Grela, Alois Fürstner, Christian Mathes: Concise total syntheses of epothilone A and C based on alkyne metatheses. In: CHEMCOMM - Chemical Communications, 2001, 1057-1059
2001Karol Leslaw Grela, M. Bieniek: Highly selective cross-metathesis with phenyl vinyl sulphone using the 'second generation' Grupps catalyst. In: Tetrahedron Lett., 2001, 6425-6428
2000Dr. Karol Leslaw Grela, Alois Fürstner, Christian Mathes, Christan W. Lehmann: Novel and Flexible Entries into Prostaglandins and Analogues Based on Ring Closing Alkyne Metathesis or Alkyne Cross Metathesis. In: J. Am. Chem. Soc., 2000, 11799-11805
2000A. Fürstner, Karol Leslaw Grela: Ringschlussmetathese von Alkinen: Anwendung auf die stereoselektive Totalsynthese von Prostaglandin-E2-1,15-Lacton. In: Angew. Chem., 2000, 1292-1294